{"product_id":"kiss-peptin-10-10vials-box","title":"Kiss Peptin-10 10vials\/box","description":"\u003cp data-pm-slice=\"1 1 []\"\u003eBasic Information\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eFull Name: Kisspeptin-10 (KP-10, Metastin 45-54)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eSequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (C-terminal amidation, RF-amide motif)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eCAS: 374675-46-7\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eMolecular Weight: ≈1302 Da\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eSource: Minimal active fragment of the precursor protein (145aa) encoded by the KISS1 gene after enzymatic digestion\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eDosage Form: Lyophilized powder\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eII. Core Mechanism (Master Switch of the Reproductive Axis)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eKP-10 is an upstream core regulator of the HPG axis (hypothalamus-pituitary-gonadal axis), with precise and potent effects:\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eReceptor Activation\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eBinding to KISS1R (GPR54, Gq\/11 coupled), mainly expressed in hypothalamic GnRH neurons\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eActivation of PLC → IP3 → Ca²⁺ release → PKC, directly depolarizing GnRH Neurons trigger pulsatile GnRH release\u003c\/p\u003e\u003cp\u003eHormonal cascade (core pathway)\u003c\/p\u003e\u003cp\u003eGnRH↑ → Pituitary release of LH (luteinizing hormone)↑, FSH (follicle-stimulating hormone)↑\u003c\/p\u003e\u003cp\u003eMale: LH↑ → Testosterone↑; FSH↑ → Sperm production↑\u003c\/p\u003e\u003cp\u003eFemale: LH↑ → Ovulation, corpus luteum formation; FSH↑ → Follicle development, estrogen↑\u003c\/p\u003e\u003cp\u003eKey characteristics\u003c\/p\u003e\u003cp\u003eMinimum activity: Only 10 peptides, containing a complete RF-amide pharmacophore, with affinity and potency comparable to the KP-54 receptor\u003c\/p\u003e\u003cp\u003eExtremely short half-life: ≈4 minutes, rapid and short-lived action, suitable for pulsatile regulation\u003c\/p\u003e\u003cp\u003ePulse dependence: Physiological pulsatile administration is necessary to effectively activate the HPG axis; continuous infusion has poor effects\u003c\/p\u003e\u003cp\u003eIII. Core functions (reproduction + metabolism + tumor)\u003c\/p\u003e\u003cp\u003e1. Reproductive regulation (most crucial)\u003c\/p\u003e\u003cp\u003ePuberty initiation: KP-10 is the \"switch\" for puberty; increased expression triggers GnRH 1. **Pulse, Initiating Sexual Development:** Hypogonadotropic hypogonadism (IHH): Restores LH\/FSH\/testosterone\/estrogen, improving secondary sexual characteristics and fertility.\u003c\/p\u003e\u003cp\u003eInfertility\/Ovulation Disorders:\u003c\/p\u003e\u003cp\u003eFemales: Induces ovulation, used for PCOS and hypothalamic amenorrhea.\u003c\/p\u003e\u003cp\u003eMales: Increases testosterone and sperm count\/motility, treating oligospermia and asthenospermia.\u003c\/p\u003e\u003cp\u003ePrecocious puberty\/Abnormal sexual development: Regulates GnRH pulses, used in central precocious puberty (CPP) research.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e2. **Metabolic and Energy Balance:** Regulates appetite, weight, and insulin sensitivity, connecting reproduction and metabolism (KNDy neurons co-express NKB\/Dyn).\u003c\/p\u003e\u003cp\u003eImproves obesity-related reproductive function decline.\u003c\/p\u003e\u003cp\u003e3. **Tumor Suppression (Metastin):** Originally named Metastin, initially discovered as a tumor metastasis suppressor.\u003c\/p\u003e\u003cp\u003eInhibits melanoma and breast cancer cell migration and invasion, induces apoptosis, and reverses EMT.\u003c\/p\u003e\u003cp\u003eIV. Dosage and Administration (Research\/Clinical Protocols)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e1. **Reconstitution:**\u003c\/p\u003e\u003cp\u003eSoluble: 0.9% benzyl alcohol antibacterial water (BAC Water), 1-2 mL Dissolve 5-10 mg\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eInstructions: Pour along the side of the bottle, gently swirl to mix, do not shake vigorously\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eStorage: Refrigerate at 2–8°C after reconstitution\u003c\/p\u003e","brand":"mySite","offers":[{"title":"KS5 5mg 10vials\/box","offer_id":42723868377134,"sku":"dlz1789826537829","price":45.0,"currency_code":"USD","in_stock":true},{"title":"KS10 10mg 10vials\/box","offer_id":42723868409902,"sku":"dlz1789826537830","price":80.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0605\/8275\/6398\/files\/4e23e4b9e5359642b3b171133835df5d328a12bf43282936007fc283e4e917f1.webp?v=1789826841","url":"https:\/\/yuanpeptide.shop\/products\/kiss-peptin-10-10vials-box","provider":"YUANPeptide","version":"1.0","type":"link"}