{"product_id":"peg-mgf-10vials-box","title":"PEG MGF 10vials\/box","description":"\u003cp data-pm-slice=\"1 1 []\"\u003eProduct Basic Information\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eFull Name: PEGylated Mechano Growth Factor, abbreviated as PEG MGF (Polyethylene Glycol Modified Mechano Growth Factor)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eEssence: A synthetic polypeptide composed of a 24-amino acid E peptide segment covalently modified with polyethylene glycol (PEG).\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eForm: Sterile lyophilized powder, individually aliquoted into vials.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eUses: Muscle repair, satellite cell activation, tissue regeneration, sports injury, sarcopenia in vitro research reagent.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eII. Mechanism of Action\u003c\/p\u003e\u003cp\u003ePEG modification significantly improves stability and half-life. Its core function focuses on the regulation of muscle stem cells, with the following mechanisms:\u003c\/p\u003e\u003cp\u003e**Local Targeted Activation:** When muscle is subjected to mechanical stress\/injury, it specifically activates muscle satellite cells (muscle stem cells), prompting them to enter the cell cycle from the resting state and expand into a pool of muscle precursor cells.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eSignal Pathway Regulation: Binding to satellite cell surface receptors, it activates the PI3K-Akt-mTOR pathway, promoting protein synthesis; simultaneously, it inhibits FoxO catabolic signaling, reducing muscle protein degradation.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eAdvantages of PEGylation: Extends the half-life of natural MGF from 5-7 minutes to 24-72 hours, reduces protease degradation and renal clearance, achieving long-lasting local effects without significantly increasing systemic IGF-1 levels, thus reducing the risk of metabolic side effects.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eRepair Timing Regulation: Preferentially drives satellite cell proliferation and inhibits premature differentiation, reserving cell sources for subsequent muscle fiber fusion and repair, complementing the repair timing of mature IGF-1.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eIII. Core Scientific Efficacy\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eMuscle Repair and Regeneration: Highly activates satellite cells in in vitro models, promoting hyperplasia and hypertrophy of myofiber, accelerating the repair of muscle defects caused by sports injuries and postoperative complications, suitable for research on muscle strains and muscle atrophy.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eAnti-Sarcopenia Research: Improves age-related satellite cell functional decline, enhances muscle mass and strength, and is used in in vitro models of age-related sarcopenia and disuse atrophy.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eTendon\/Cartilage Repair: Promotes the proliferation of tendon cells and chondrocytes and matrix synthesis, suitable for research on the repair mechanisms of Achilles tendon injuries and osteoarthritis.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eLocal tissue protection: Reduces muscle cell apoptosis caused by ischemia\/reperfusion, used in experiments protecting against myocardial ischemia and limb ischemia-reperfusion injury.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eCombined use studies: Often used in combination with TB-500, BPC-157, and IGF-1 LR3 to conduct multi-target muscle repair and tissue regeneration combined experiments.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eIV. Reconstitution and Storage Guidelines\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eReconstitution solvent: Reconstitute the lyophilized powder with sterile water for injection or 0.9% physiological saline, gently vortex to mix, do not shake violently.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eStorage requirements\u003c\/p\u003e\u003cp\u003eUnopened: Refrigerate at 2-8℃ protected from light. Do not freeze to prevent damage to the PEG-peptide structure.\u003c\/p\u003e\u003cp\u003eAfter reconstitution: Store at 4℃ protected from light.\u003c\/p\u003e","brand":"mySite","offers":[{"title":"Default Title","offer_id":42723869556782,"sku":"dlz1789826545356","price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0605\/8275\/6398\/files\/887f7374d28ebef4631d7f53605032a431b3cbabc2bafb4de9d559e2bb0a1ade.webp?v=1789826849","url":"https:\/\/yuanpeptide.shop\/products\/peg-mgf-10vials-box","provider":"YUANPeptide","version":"1.0","type":"link"}