{"product_id":"retatrutide-10vials-box","title":"Retatrutide 10vials\/box","description":"\u003cp data-pm-slice=\"1 1 []\"\u003eBasic Information\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eDrug Classification: Triple receptor agonist, simultaneously activating GLP-1R \/ GIPR \/ GCGR (glucagon, glucose-dependent insulinotropic peptide, glucagon-like peptide-1)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eDeveloper: Eli Lilly\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eMolecular Properties: Long-acting modified peptide\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eIndications and Development Direction: Type 2 diabetes, chronic obesity weight loss, metabolic syndrome, fatty liver\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eDosage Form: Medical pre-filled pen; research channel lyophilized powder, solvent universal 0.9% benzyl alcohol antibacterial solution\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eApproval Progress: FDA is currently reviewing the weight loss indication; Phase III clinical data show weight loss efficacy far exceeding semaglutide and telpoxetine.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eII. Triple Mechanism of Action (Core Advantages)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eGLP-1 Pathway: Glucose-dependent insulinotropic peptide, glucagon inhibition, delayed gastric emptying, potent hypothalamic appetite suppression, reducing calorie intake.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eGIP Pathway: Synergistically amplifies blood glucose lowering and weight loss effects, enhances pancreatic islet sensitivity, and reduces inflammation.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eGCGR (Glucagon Receptor Mild Agonist) mildly activates lipolysis, increases energy expenditure, reduces visceral fat, and improves liver fat accumulation; Unlike glucagon alone, this product is a selective, mild agonist and will not significantly raise blood sugar.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThe three effects work together to achieve four benefits: blood sugar control effective fat reduction increased basal metabolism improved NAFLD.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eIII. Core Clinical Effects (Phase III Data)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eWeight Loss (Maximum Dose 12 mg weekly)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eAverage weight loss over 6 months: 24%-30% of baseline weight\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eMany participants achieved weight loss exceeding 25%, with a significant reduction in visceral fat, superior to Tirzepatide and Semaglutide.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eGlucose Control\u003c\/p\u003e\u003cp\u003eSignificantly reduced glycated HbA1c with a high target achievement rate and extremely low risk of hypoglycemia (glucose-dependent effect).\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eMetabolic Improvement\u003c\/p\u003e\u003cp\u003eSignificantly improved triglycerides, blood pressure, and insulin resistance; significantly reduced intrahepatic fat content in non-alcoholic fatty liver disease.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eCardiovascular Benefits\u003c\/p\u003e\u003cp\u003eReduced weight-related cardiovascular risk factors and decreased inflammatory markers.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eIV. Standard Dosing Step-Up Regimen (Clinical Recommendation)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eInitial 4 weeks: 2 mg\/week\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eNext 4 weeks: 4 mg\/week\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eMaintenance: 6 mg → 8 mg → 12 mg (adjusted based on tolerance and weight loss goals)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eMaximum Recommended Maintenance Dose: 12 mg Once a week\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eV. Common Side Effects (Dose-dependent, relieved by increasing dosage)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eGastrointestinal (most common): Nausea, vomiting, diarrhea, vomiting, bloating, constipation, significant loss of appetite; usually gradually tolerated over the first 1-2 months.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eOther minor reactions: Redness, swelling, and itching at the injection site; fatigue; mild increase in heart rate; belching.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eSevere High Risk (Immediately Discontinue Medication and Seek Medical Attention)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eAcute Pancreatitis: Persistent severe upper abdominal pain, vomiting; contraindicated in individuals with a history of pancreatitis.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eFamily history of medullary thyroid carcinoma \/ MEN2 syndrome: Absolutely contraindicated (common black box warning for all GLP-1 drugs).\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eSevere and persistent dehydration, acute kidney injury (induced by vomiting, diarrhea, and insufficient rehydration).\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eIncreased risk of gallstones and cholecystitis (high incidence in individuals undergoing rapid weight loss).\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eSevere hypoglycemia (increased risk when used in combination with insulin or sulfonylureas).\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eVI. Absolute Contraindications\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003ePersonal\/family history of medullary thyroid carcinoma, multiple endocrine adenomas type 2 (MEN2).\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003ePregnant, women planning pregnancy, and breastfeeding women.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eType 1 diabetes, diabetic ketoacidosis.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eHistory of severe pancreatitis.\u003c\/p\u003e","brand":"mySite","offers":[{"title":"RT5 5mg 10vials\/box","offer_id":42723870998574,"sku":"dlz1789826548686","price":40.0,"currency_code":"USD","in_stock":true},{"title":"RT10 10mg 10vials\/box","offer_id":42723871031342,"sku":"dlz1789826548687","price":80.0,"currency_code":"USD","in_stock":true},{"title":"RT15 15mg 10vials\/box","offer_id":42723871064110,"sku":"dlz1789826548688","price":110.0,"currency_code":"USD","in_stock":true},{"title":"RT20 20mg 10vials\/box","offer_id":42723871096878,"sku":"dlz1789826548689","price":140.0,"currency_code":"USD","in_stock":true},{"title":"RT30 30mg 10vials\/box","offer_id":42723871129646,"sku":"dlz1789826548690","price":190.0,"currency_code":"USD","in_stock":true},{"title":"RT40 40mg 10vials\/box","offer_id":42723871162414,"sku":"dlz1789826548691","price":240.0,"currency_code":"USD","in_stock":true},{"title":"RT50 50mg 10vials\/box","offer_id":42723871195182,"sku":"dlz1789826548692","price":290.0,"currency_code":"USD","in_stock":true},{"title":"RT60 60mg 10vials\/box","offer_id":42723871227950,"sku":"dlz1789826548693","price":340.0,"currency_code":"USD","in_stock":true},{"title":"RT80 80mg 10vials\/box","offer_id":42723871260718,"sku":"dlz1789826548694","price":420.0,"currency_code":"USD","in_stock":true},{"title":"RT100 100mg 10vials\/box","offer_id":42723871293486,"sku":"dlz1789826548695","price":500.0,"currency_code":"USD","in_stock":true},{"title":"RT120 120mg 10vials\/box","offer_id":42723871326254,"sku":"dlz1789826548696","price":560.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0605\/8275\/6398\/files\/f77380035f0f800ab6a24306fc228920283ff7c58cddc33c403a0ebc677b6168.webp?v=1789826859","url":"https:\/\/yuanpeptide.shop\/products\/retatrutide-10vials-box","provider":"YUANPeptide","version":"1.0","type":"link"}