{"product_id":"thymalin-10vials-box","title":"Thymalin 10vials\/box","description":"\u003cp data-pm-slice=\"1 1 []\"\u003eBasic Product Information\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eFull Name: Thymalin (Thymic Peptide Complex)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eCAS Number: 79621-14-0 (Natural Extract); 84006-44-2 (Core Active Dipeptide EW)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eSource \/ Ingredients:\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eNatural Type: A mixture of polypeptides extracted from calf thymus tissue using mild acid extraction. The core active ingredients are EW (Glu-Trp, Thymogen), KE (Lys-Glu, Vilon), and EDP (Glu-Asp-Pro, Crystagen).\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eSynthetic Type: A standardized synthetic dipeptide with **L-Glu-L-Trp (EW, 333.34 Da)** as its core.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eAppearance: White\/off-white sterile lyophilized powder with good water solubility.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003ePurity: HPLC ≥98%, endotoxin-free, research-grade.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eResearch Positioning: A thymus-targeted immunomodulator, focusing on immune homeostasis reconstruction, aging immune reversal, and immune protection against radiotherapy and chemotherapy.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eII. Core Mechanism of Action (Dual Pathway of Gene Regulation + Immune Remodeling)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e1. Epigenetics and Gene Expression Regulation (Core Mechanism)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eActive short peptides (EW\/KE\/EDP) directly bind to specific sequences in the minor groove of DNA (GGAG\/AGAC) and histones, regulating the transcription of immune-related genes and non-mutantly altering gene expression patterns.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eUpregulating Foxn1 (a core transcription factor in thymic epithelial cells) and TSLP\/IL-7 reverses thymic atrophy and restarts T cell production.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eInhibiting the NF-κ B pathway and downregulating pro-inflammatory factors such as IL-1β, IL-6, and TNF-α, balancing immune inflammation.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e2. Hematopoietic Stem Cell and T Cell Maturation Driver\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eReducing the stem cell marker CD44\/CD117 promotes the directed differentiation of hematopoietic stem cells into T lymphocytes.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eSignificantly increasing the expression of mature CD28⁺ T cells (up to +6.8-fold), rebuilding the CD4⁺\/CD8⁺ T cell pool.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eActivating NK cell activity and quantity, enhancing innate immune surveillance and anti-tumor capabilities.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e3. Anti-apoptosis and Antioxidant Effects of Immune Cells\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eReduce oxidative stress damage to lymphocytes and decrease apoptosis induced by radiotherapy, chemotherapy, and aging.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eUpregulate heat shock proteins, enhance cellular stress tolerance, and protect bone marrow hematopoietic function.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eIII. Core Research Applications\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eAging Immune Reversal (Immunoaging Model): Intervention for thymic degeneration, recurrent infections, and immunodeficiency in the elderly, restoring naive T cell output.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eRadiotherapy\/Chemotherapy Immune Protection: Alleviating leukopenia, lymphocyte depletion, and long-term immunosuppression caused by chemotherapy\/radiotherapy.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eViral Infection Immune Reconstitution: Immune repair for respiratory viruses, hepatitis, and chronic persistent infections, enhancing antiviral responses.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eTumor Immunotherapy Combined Research: Single-drug or combined immune checkpoint inhibitors to reshape the tumor microenvironment and eliminate immune escape.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eAutoimmune Balance: Regulating chronic low-grade inflammation and immune dysregulation for in vitro controlled experiments on autoimmune diseases.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eAnti-aging and Lifespan Research: Intervening in telomere-related genes to delay cellular aging and explore mechanisms for maintaining health in the elderly.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eIV. Reconstitution and Storage Specifications\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eReconstitution\u003c\/p\u003e\u003cp\u003eSolubilizers: Sterile water for injection, 0.9% physiological saline, 0.6%... Acetic acid aqueous solution\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eHandling: Gently invert to dissolve; avoid vigorous shaking to prevent peptide chain breakage.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eStorage: Unopened lyophilized powder: Short-term refrigeration at 2-8℃; long-term storage at -20℃, sealed and protected from light; shelf life ≥24 months.\u003c\/p\u003e","brand":"mySite","offers":[{"title":"TY10 10mg 10vials\/box","offer_id":42723869851694,"sku":"dlz1789826546019","price":70.0,"currency_code":"USD","in_stock":true},{"title":"TY20 10mg 10vials\/box","offer_id":42723869884462,"sku":"dlz1789826546020","price":130.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0605\/8275\/6398\/files\/36666ff840b85fa0214b94b2f2cfec4e572fff900285d06808f32657b147e33e.webp?v=1789826851","url":"https:\/\/yuanpeptide.shop\/products\/thymalin-10vials-box","provider":"YUANPeptide","version":"1.0","type":"link"}