{"product_id":"tirzepatide-10vials-box","title":"Tirzepatide 10Vials\/box","description":"\u003cp data-pm-slice=\"1 1 []\"\u003eBasic Information\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eGeneric Name: Tirzepatide\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eBrand Names: Mounjaro, Zepbound (for weight loss)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eDeveloped\/Marketed by: Eli Lilly; FDA approved in 2022 (diabetes), FDA approved in 2023 (weight loss), approved in China in 2024\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eMolecular Type: Peptide, GIP\/GLP-1 dual receptor agonist\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eSpecifications: Multi-dose pen, containing 2.5mg, 5mg, 10mg, and 15mg doses\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eII. Core Mechanism of Action (Dual-Target Synergistic Effect)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e1. GLP-1 Receptor Activation\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eBlood Sugar Reduction: Glucose-dependent insulin secretion stimulation, glucagon inhibition, reduced hepatic glucose output\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eWeight Loss: Delayed gastric emptying, increased satiety, central appetite suppression\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e2. GIP Receptor Activation\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eImproved insulin sensitivity, improved β-cell function\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003ePromoted lipolysis, reduced visceral fat, protected muscle mass\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eRelief of GLP-1 Common gastrointestinal reactions to monotherapy, such as nausea and vomiting.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eIII. Indications (Clinically Approved)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eType 2 Diabetes in Adults: Can be used alone or in combination for patients with poor control through diet\/exercise\/monotherapy.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eLong-term weight management in obese\/overweight adults.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eObesity: BMI ≥ 28 kg\/m²\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eOverweight: BMI ≥ 24 kg\/m² at least one weight-related complication (hypertension, hyperlipidemia, OSA, cardiovascular disease, etc.)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eModerate to severe obstructive sleep apnea (OSA) in obese adults.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eIV. Dosage and Administration (Standard Regimen)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eStarting dose: 2.5 mg once weekly for 4 weeks (adaptation period)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eIncrease dose: 2.5 mg every 4 weeks, up to a maximum of 15 mg\/week\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eMaintenance:\u003c\/p\u003e\u003cp\u003eDiabetes\/Weight Loss: 5 mg, 10 mg, 15 mg (as needed)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eOSA: 10 mg, 15 mg\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eV. Core Clinical Efficacy\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e1. Blood Glucose Reduction\u003c\/p\u003e\u003cp\u003eSignificantly reduces HbA1c, with a maximum reduction of... 2.0%+, superior to single-target GLP-1 receptor agonists\u003c\/p\u003e\u003cp\u003eExtremely low risk of hypoglycemia (glucose-dependent onset)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e2. Weight loss (milestone)\u003c\/p\u003e\u003cp\u003e15mg\/week, 52 weeks: Average weight loss 16-22kg (17%-22% of initial body weight)\u003c\/p\u003e\u003cp\u003eChinese population: 15mg group, average weight loss 16.1kg (17.5%) over 52 weeks, 87.7% achieved ≥5% weight loss\u003c\/p\u003e\u003cp\u003eWeight loss approaching the effect of partial bariatric surgery, superior to smegglutide\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e3. Metabolic improvement\u003c\/p\u003e\u003cp\u003eLowering triglycerides, increasing… HDL, improves blood pressure, reduces waist circumference\u003c\/p\u003e\u003cp\u003eImproves non-alcoholic fatty liver disease (NAFLD), reduces liver fat, and lowers the risk of liver fibrosis\u003c\/p\u003e\u003cp\u003eReduces the risk of major cardiovascular adverse events (myocardial infarction, stroke)\u003c\/p\u003e\u003cp\u003eVI. Adverse Reactions (mostly mild to moderate, mostly transient)\u003c\/p\u003e\u003cp\u003eCommon (30%-40%)\u003c\/p\u003e\u003cp\u003eGastrointestinal: nausea, diarrhea, vomiting, constipation, decreased appetite (significant in the initial stage of treatment, alleviates with adaptation)\u003c\/p\u003e\u003cp\u003eRare \/ Caution Required\u003c\/p\u003e\u003cp\u003ePancreatitis, gallbladder disease (incidence not significantly different from placebo)\u003c\/p\u003e\u003cp\u003eHypoglycemia (dosage reduction required when used in combination with insulin\/sulfonylureas)\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eVII. Contraindications and Cautions\u003c\/p\u003e\u003cp\u003eAbsolute Contraindications\u003c\/p\u003e\u003cp\u003eMedullary thyroid carcinoma (MTC)\u003c\/p\u003e\u003cp\u003ePersonal\/family history\u003c\/p\u003e\u003cp\u003eMEN 2 type multiple endocrine adenoma syndrome (MEN 2)\u003c\/p\u003e\u003cp\u003eSevere hypersensitivity to telpolide or excipients\u003c\/p\u003e\u003cp\u003ePregnancy\/ Use with caution during lactation. Contraindicated in patients with a history of pancreatitis, severe gastrointestinal disease, moderate to severe renal insufficiency, severe hepatic insufficiency, or at risk of diabetic retinopathy.\u003c\/p\u003e\u003cp\u003eVIII. Storage and Handling\u003c\/p\u003e\u003cp\u003eUnopened: Refrigerate at 2-8℃, protected from light, do not freeze.\u003c\/p\u003e\u003cp\u003eOpened pen: Store at room temperature ≤30℃ for 28 days, or refrigerate at 2-8℃.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eNote: Remaining medication in the pen should not be reused.\u003c\/p\u003e\u003cp\u003eIX. Combination Therapy (Commonly Used Clinically)\u003c\/p\u003e\u003cp\u003eDiabetes: Tepalpitide Metformin \/ SGLT-2 Inhibitor\u003c\/p\u003e\u003cp\u003eWeight Loss Metabolic Ailment: Tepalpitide Diet Control Exercise\u003c\/p\u003e\u003cp\u003eOSA: Tepalpitide Continuous Positive Airway Pressure (CPAP)\u003c\/p\u003e\u003cp\u003eNAFLD: Tepalpitide Lifestyle Intervention\u003c\/p\u003e","brand":"mySite","offers":[{"title":"TR5 5mg 10Vials\/box","offer_id":42723866738734,"sku":"dlz1789826533525","price":40.0,"currency_code":"USD","in_stock":true},{"title":"TR10 10mg 10Vials\/box","offer_id":42723866771502,"sku":"dlz1789826533526","price":70.0,"currency_code":"USD","in_stock":true},{"title":"TR15 15mg 10Vials\/box","offer_id":42723866804270,"sku":"dlz1789826533527","price":100.0,"currency_code":"USD","in_stock":true},{"title":"TR20 20mg 10Vials\/box","offer_id":42723866837038,"sku":"dlz1789826533528","price":130.0,"currency_code":"USD","in_stock":true},{"title":"TR30 30mg 10Vials\/box","offer_id":42723866869806,"sku":"dlz1789826533529","price":180.0,"currency_code":"USD","in_stock":true},{"title":"TR40 40mg 10Vials\/box","offer_id":42723866902574,"sku":"dlz1789826533530","price":230.0,"currency_code":"USD","in_stock":true},{"title":"TR50 50mg 10Vials\/box","offer_id":42723866935342,"sku":"dlz1789826533531","price":280.0,"currency_code":"USD","in_stock":true},{"title":"TR60 60mg 10Vials\/box","offer_id":42723866968110,"sku":"dlz1789826533532","price":330.0,"currency_code":"USD","in_stock":true},{"title":"TR80 80mg 10Vials\/box","offer_id":42723867000878,"sku":"dlz1789826533533","price":400.0,"currency_code":"USD","in_stock":true},{"title":"TR100 100mg 10Vials\/box","offer_id":42723867033646,"sku":"dlz1789826533534","price":460.0,"currency_code":"USD","in_stock":true},{"title":"TR120 120mg 10Vials\/box","offer_id":42723867066414,"sku":"dlz1789826533535","price":520.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0605\/8275\/6398\/files\/511b32dca1badabce2ec143a249e81110d57e3f223c29637219b3c6e91b182e1.webp?v=1789826830","url":"https:\/\/yuanpeptide.shop\/products\/tirzepatide-10vials-box","provider":"YUANPeptide","version":"1.0","type":"link"}