{"product_id":"vip","title":"VIP","description":"\u003cp data-pm-slice=\"1 1 []\"\u003eBasic Information\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eFull Name: Vasoactive Intestinal Peptide (VIP)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eCAS: 37221-74-2\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eAmino Acids: 28 (His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eFamily: Secretin-Glucagon Superfamily (68% homology with PACAP)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eMolecular Weight: 3326 Da\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eAppearance: White lyophilized powder, highly water-soluble\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eReceptors: VPAC1, VPAC2 (G protein-coupled receptors, activate the cAMP pathway)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eII. Core Mechanism of Action\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eReceptor Activation: Binding to VPAC1\/2 → Adenylate cyclase↑ → cAMP↑ → PKA Activation → Downstream Effects\u003c\/p\u003e\u003cp\u003eVasodilation: Directly relaxes vascular smooth muscle, promotes NO release → lowers blood pressure, increases local blood flow\u003c\/p\u003e\u003cp\u003eGastrointestinal Regulation: Relaxes gastrointestinal smooth muscle, stimulates water\/electrolyte secretion, inhibits gastric acid, promotes pancreatic juice\/bile secretion\u003c\/p\u003e\u003cp\u003eImmunosuppression: Inhibits NF-κ B → downregulates TNF-α\/IL-6\/IL-12; amplifies Tregs, induces DC tolerance → anti-inflammatory\/immune tolerance\u003c\/p\u003e\u003cp\u003eNeural Function: Central neurotransmitters, neuroprotection, promotes nerve growth, regulates circadian rhythms (SCN core signal)\u003c\/p\u003e\u003cp\u003eIII. Main Physiological\/Pharmacological Effects\u003c\/p\u003e\u003cp\u003e1. Cardiovascular System\u003c\/p\u003e\u003cp\u003ePowerful vasodilation (peripheral\/lung\/brain), reduces pulmonary artery pressure (PAH)\u003c\/p\u003e\u003cp\u003ePositive inotropic effect, mild heart rate increase\u003c\/p\u003e\u003cp\u003eImproves microcirculation, resists ischemia-reperfusion injury\u003c\/p\u003e\u003cp\u003e2. Digestive System\u003c\/p\u003e\u003cp\u003eRelaxation of lower esophageal sphincter, regulation of gastrointestinal motility\u003c\/p\u003e\u003cp\u003eStimulates pancreatic juice\/bile\/intestinal juice secretion (water + electrolytes)\u003c\/p\u003e\u003cp\u003eInhibits gastric acid secretion, protects gastric mucosa\u003c\/p\u003e\u003cp\u003e3. Respiratory System\u003c\/p\u003e\u003cp\u003eBronchiectasis (potential target for asthma)\u003c\/p\u003e\u003cp\u003eReduces pulmonary vascular resistance, improves oxygenation\u003c\/p\u003e\u003cp\u003e4. Immunity and Inflammation\u003c\/p\u003e\u003cp\u003eInhibits macrophage\/neutrophil activation\u003c\/p\u003e\u003cp\u003eInhibits pro-inflammatory factors, promotes anti-inflammatory factors (IL-10)\u003c\/p\u003e\u003cp\u003ePotential treatment for autoimmune diseases, chronic inflammation, long-term COVID-19, and CIRS\u003c\/p\u003e\u003cp\u003e5. Neuroendocrine System\u003c\/p\u003e\u003cp\u003eCentral neurotransmitters (learning, memory, mood)\u003c\/p\u003e\u003cp\u003eNeuroprotection, anti-apoptosis, promotes nerve regeneration\u003c\/p\u003e\u003cp\u003eRegulates prolactin, growth hormone, and cortisol release\u003c\/p\u003e\u003cp\u003eSuprachiasmatic nucleus (SCN) core rhythm signal\u003c\/p\u003e\u003cp\u003eIV. Clinical\/Research Applications\u003c\/p\u003e\u003cp\u003e1. Validated Indications (Clinical\/Research)\u003c\/p\u003e\u003cp\u003eVIPoma (vasoactive intestinal peptide tumor): Watery diarrhea, hypokalemia, hypoacidity (WDHA syndrome), significantly elevated plasma VIP\u003c\/p\u003e\u003cp\u003ePulmonary hypertension (PAH): Selective pulmonary vasodilation, improves hemodynamics\u003c\/p\u003e\u003cp\u003eAsthma\/ COPD: Bronchiectasis, anti-inflammatory\u003c\/p\u003e\u003cp\u003eInflammatory Bowel Disease (IBD): Suppressing intestinal inflammation, protecting the mucosa\u003c\/p\u003e\u003cp\u003eAutoimmune Diseases: Rheumatoid arthritis, multiple sclerosis, psoriasis\u003c\/p\u003e\u003cp\u003eLong-term COVID-19\/Chronic Inflammatory Response Syndrome (CIRS): Immune reset, improving fatigue\/cognition\u003c\/p\u003e\u003cp\u003eNeuroprotection: Stroke, Alzheimer's disease, Parkinson's disease models\u003c\/p\u003e\u003cp\u003eCircadian Rhythm Disorders: Regulating the sleep-wake cycle\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e2. Research Directions\u003c\/p\u003e\u003cp\u003eNeuro-Immune-Endocrine Network Regulation\u003c\/p\u003e\u003cp\u003eInflammation and Immune Tolerance Mechanisms\u003c\/p\u003e\u003cp\u003eOrgan Ischemia-Reperfusion Protection\u003c\/p\u003e\u003cp\u003eStem Cell Proliferation and Differentiation Regulation\u003c\/p\u003e\u003cp\u003eAging and Mitochondrial Function Protection\u003c\/p\u003e","brand":"mySite","offers":[{"title":"VIP5 5mg 10vials\/box","offer_id":42723864969262,"sku":"dlz1789826524913","price":110.0,"currency_code":"USD","in_stock":true},{"title":"VIP10 10mg 10vials\/box","offer_id":42723865002030,"sku":"dlz1789826524914","price":200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0605\/8275\/6398\/files\/d5439e3dbe74bcb384ba4e63210ba737b7cac03f8599f8db84a3de280fd206ce.webp?v=1789826814","url":"https:\/\/yuanpeptide.shop\/products\/vip","provider":"YUANPeptide","version":"1.0","type":"link"}