AICAR 10vials/box

Basic Information

Full Name: 5-Aminoimidazole-4-carboxamide ribonucleoside (AICA ribonucleoside)

Synonyms: Acadesine

CAS: 2627-69-2

Type: Nucleoside analog (non-peptide), small molecule AMP mimic

Dosage Form: Lyophilized powder

II. Core Mechanism of Action (Mimicking the "energy signal" of motion)

Intracellular Transformation: After entering the cell, AICAR is phosphorylated to ZMP (AICAR monophosphate), which has a structure highly similar to AMP.

Activation of AMPK: ZMP binds to the γ subunit of AMPK, mimicking an "energy-deficient" state, strongly activating AMPK (the metabolic master switch) without altering actual ATP levels.

Downstream Effects (Sports-Related):

Fat Burning: Promotes fatty acid oxidation and inhibits fat synthesis.

Glycolic Control: Increases muscle GLUT4 transport, improves insulin sensitivity, and reduces hepatic glucose output.

Endurance Enhancement: Activates PGC-1α, promotes mitochondrial formation, and increases type I oxidative muscle fibers.

Anti-inflammatory: Inhibits NF-κ B and reduces inflammatory factors (such as CRP).

III. Core Efficacy (Scientific Research/Preclinical Data)

1. Exercise Simulation (Most Well-Known):

Human Body: Improves aerobic endurance, delays lactic acid buildup, and reduces exercise fatigue.

2. Fat Reduction and Metabolic Optimization

Prioritizes visceral fat reduction while preserving lean body mass (more noticeable during dieting)

Improves insulin resistance, lowers blood sugar, and improves fatty liver

Boosts basal metabolic rate and increases the proportion of energy derived from fat

3. Other Potential Benefits

Myocardial protection (ischemia-reperfusion injury)

Neurological protection, improves diabetic neuropathy

Anti-inflammatory and anti-aging (mitochondrial health)

IV. Dosage and Administration (Research/Non-clinical Protocol)

1. Reconstitution

Soluble: 0.9% benzyl alcohol antibacterial water (BAC Water), 1-2 mL to dissolve 50-100 mg lyophilized powder

Procedure: Slowly pour along the side of the bottle, gently swirl to mix, do not shake vigorously

Storage: Refrigerate at 2-8°C after reconstitution