ARA290 (Cibinetide) 10vials/box

Basic Information

Full Name: Cibinetide (ARA-290, Helix B Surface Peptide, HBSP)

Sequence: 11 peptides, pyroGlu-Glu-Glu-Leu-Arg-Ala-Leu-Asn-Ser-Ser (EPO helical B region)

CAS: 1208243-50-8

Molecular Weight: ≈1257 Da

Dosage Form: Lyophilized Powder

II. Core Mechanism (Precise Repair, No Hematopoietic Risk)

ARA290's biggest breakthrough: It only activates the tissue repair receptor (IRR), without activating the classical EPO receptor, completely separating EPO's repair/anti-inflammatory and hematopoietic functions.

Receptor Selectivity

Binding IRR (EPOR+CD131 heterodimer): Expressed only during injury/inflammation/stress, almost absent in normal tissues, achieving precise targeted repair.

Not binding EPOR homodimer: Does not increase red blood cell count, does not increase blood viscosity, and has no risk of thrombosis.

Downstream Signaling (Repair Trio)

Anti-inflammatory: Inhibits TNF-α, IL-1β, IL-6, and NF-κ B, reducing macrophage/microglia activation and blocking neuroinflammation.

Anti-apoptosis: Activates JAK2/STAT5 and PI3K/Akt, protecting neurons, endothelial cells, and pancreatic islets from apoptosis.

Repair and Regeneration: Promotes small fiber regeneration, angiogenesis, endothelial repair, and mitochondrial protection.

Analgesic Mechanism: Directly antagonizes TRPV1 (a pain sensitization channel), rapidly relieving burning, tingling, and numbness-related neuropathic pain.

III. Core Efficacy (Clinical/Scientific Validation)

1. Nerve Repair (Core Function)

Small Fiber Neuropathy (SFN): Phase II clinical trials confirmed that it increases corneal/epidermal nerve fiber density, improves pain/temperature sensation, and reduces numbness/tingling.

Indications: Diabetic peripheral neuropathy, sarcoidosis-related neuropathy, chemotherapy/traumatic neuralgia, and long-term COVID-19 nerve damage.

Mechanism: Stimulates Schwann cell and nerve axon regeneration, repairing myelin sheath and nerve conduction.

2. Anti-inflammatory and Tissue Protection

Systemic Anti-inflammatory: Reduces inflammatory factors, improves autoimmunity, chronic inflammation, and ischemia-reperfusion injury.

Vascular/Endothelial Repair: Improves microcirculation, protects the endothelium, reduces leakage, and is used for diabetic macular edema and limb ischemia.

Metabolic Protection: Improves insulin sensitivity, protects pancreatic β cells, and slows the progression of diabetes.

Organ Protection: Protects against damage to multiple organs including the myocardium, kidneys, nerves, and retina.

3. Other Potential

Antidepressant/Mood Improvement: Reduces neuroinflammation, supports brain repair, and improves depression and cognition.

Wound Healing: Promotes granulation tissue, angiogenesis, and collagen formation, accelerating the repair of chronic wounds.

IV. Dosage and Administration (Research/Clinical Protocol)

1. Reconstitution

Solvent: 0.9% benzyl alcohol antibacterial water (BAC Water), 1-2 mL to dissolve 10 mg lyophilized powder

Procedure: Pour along the side of the vial, gently swirl to mix, do not shake vigorously

Storage: Refrigerate at 2-8°C after reconstitution.