Cardiogen 10vials/box

Product Basic Information

Full Name: Cardiogen (AEDR, Cardiac Regulatory Peptide)

Sequence: Ala-Glu-Asp-Arg (AEDR), Tetrapeptide

CAS Number: 857267-11-9

Molecular Formula: C₁₈H₃₁N₇O₉, Molecular Weight: 489.48 Da

Appearance: White/off-white sterile lyophilized polypeptide powder, individually dispensed in vials

Purity: HPLC ≥ 98%

Solubility: Easily soluble in water, PBS, DMSO

Uses: In vitro research reagent for cardiomyocyte repair, cardiovascular function regulation, anti-myocardial fibrosis, and selective regulation of tumor cells

II. Mechanism of Action (Research Level)

Cardiogen belongs to the Khavinson tissue-specific bioregulatory peptides, and its core function is mediated through the regulation of nuclear gene expression:

Cardiomyocyte protection and anti-apoptosis: Inhibits p53 protein expression in cardiomyocytes, reducing cardiomyocyte apoptosis; promotes cardiomyocyte proliferation, and improves the cell viability of aging/damaged myocardium.

**Fibroblast Regulation and Anti-fibrosis:** Targets and regulates fibroblast activity, reducing pathological collagen deposition and myocardial fibrosis, and improving myocardial remodeling.

**Dual Cell Selectivity:** Protects healthy cardiomyocytes and inhibits their apoptosis; simultaneously induces tumor cell apoptosis, exhibiting unique cellular environment selectivity.

**Gene Expression Regulation:** Penetrates the cardiomyocyte nucleus, binds to DNA promoter regions, regulates the transcription of myocardial function-related genes, and restores myocardial metabolism and contractile function.

**III. Core Research Efficacy:**

* **Myocardial Injury Repair:** Applicable to in vitro model studies of myocardial ischemia, post-myocardial infarction repair, cardiomyocyte aging, and myocardial fibrosis.

* **Cardiovascular Function Regulation:** Improves myocardial metabolism, enhances myocardial contractility, and alleviates age-related cardiovascular function decline.

* **Anti-fibrosis Research:** Inhibits pathological fibrosis in myocardium, blood vessels, and other tissues, used to explore the repair mechanisms of chronic cardiovascular injury.

* **Tumor and Cell Selectivity Research:** Explores the differential regulatory mechanisms of healthy cells/tumor cells, used in research at the intersection of tumor and tissue repair.

* **Joint Research Applications:** Can be used in conjunction with Vesugen (vascular peptide), BPC-157, and GHK-Cu to conduct synergistic experiments on cardiovascular-tissue repair.

** IV. Reconstitution and Storage Guidelines

Reconstitution Solvents: Sterile water for injection, 0.6% acetic acid aqueous solution, and PBS can all be used to prepare the working solution. Mix gently; vigorous shaking is prohibited.

Storage Requirements

Unopened lyophilized powder: Store at -20°C, protected from light, sealed, and frozen. Stable for ≥2 years.

Reconstituted liquid: Refrigerate at 4°C, protected from light.