MGF 10vials/box

MGF (Mechano Growth Factor, IGF-1Ec) Internal Product Introduction (No Injection Dosage, Includes a Standard Disclaimer)

I. Basic Product Information

Full Name: MGF (Mechano Growth Factor), a muscle/mechanical stress-specific IGF-1 splice variant (human IGF-1Ec, rodent IGF-1Eb)

Core Active Fragment: C- terminal 24-amino acid E peptide (Ec peptide), the key functional region

Amino Acid Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-NH₂

CAS Number: No publicly available standard CAS (Specifically for Scientific Research Peptides)

Molecular Formula: C₁₂₄H₂₀₄N₄₂O₄₁S₁

Molecular Weight: Approx. 2972 Da

Appearance: White/off-white sterile lyophilized powder, good water solubility

Uses: Reagent for in vitro scientific research experiments related to muscle satellite cell activation, muscle fiber repair and hypertrophy, sports injury repair, age-related sarcopenia, cartilage/bone regeneration, and cardiomyocyte protection

II. Mechanism of Action

Mechanism of Action

Mechanical Stress Response and Local Activation (Core): When muscles are subjected to mechanical stretching, injury, or hypoxia, the IGF-1 gene undergoes selective splicing, rapidly expressing MGF; its unique C- terminal E peptide, independent of the mature IGF-1 structure, activates the signaling pathway through an unknown specific receptor (non-IGF-1R).

Satellite Cell Proliferation Regulation: Preferentially activates resting muscle satellite cells (muscle stem cells), promoting their rapid proliferation, expanding the muscle precursor cell pool, inhibiting premature differentiation, and reserving a large number of cell sources for muscle fiber repair.

Muscle fiber repair and hypertrophy: Accelerates the regeneration of damaged muscle fibers, increasing muscle fiber cross-sectional area and muscle mass; enhances muscle adaptability to mechanical loads and promotes post-exercise supercompensation.

Anti-apoptosis and tissue protection: Inhibits apoptosis of myocytes, chondrocytes, and cardiomyocytes, reducing cell death caused by injury, aging, and oxidative stress.

Cross-tissue repair effects: Acts on chondrocytes, promoting their proliferation, migration, and matrix synthesis, repairing articular cartilage damage; provides protection for cardiomyocytes, improving ischemia-reperfusion injury.

Reversal of aging muscle function: Reverses the decline in MGF expression in aging muscles, restores the responsiveness of satellite cells to mechanical stimulation, and delays the progression of sarcopenia.

III. Core Research Efficacy

Sports Injuries and Postoperative Repair: In vitro mechanism research for muscle strains, tears, post-exercise micro-injuries, and post-orthopedic surgery muscle/cartilage repair.

Sarcopenia and aging muscle research: Explores intervention strategies for aging muscle atrophy, strength decline, and satellite cell function deterioration.

* **Muscle Hypertrophy and Resistance Training Mechanisms:** Investigating the molecular pathways and local regulatory targets of resistance training-induced muscle mass growth and strength enhancement.

* **Cartilage and Bone Regeneration:** Studying the repair mechanisms of osteoarthritis, cartilage defects, and fracture healing.

* **Myocardial Protection and Ischemia Repair:** Developing research models for myocardial cell protection and functional recovery after myocardial ischemia and myocardial infarction.

* **Combined Research Systems:** Often combined with BPC-157, TB-500, Cortagen, and Chonluten to construct multi-target tissue repair complex research protocols involving muscle, cartilage, nerves, and immunity.

* **IV. Reconstitution and Storage Specifications:**

**Reconstitution Solvents:** Sterile water for injection, physiological saline, or 0.9% sodium chloride solution can all be used.

* **Storage Requirements:**

**Unopened Lyophilized Powder:** Store at -20°C protected from light. Shelf life: 12-24 months.

**Reconstituted Liquid:** Store at 4°C protected from light.