Kiss Peptin-10 10vials/box

Basic Information

Full Name: Kisspeptin-10 (KP-10, Metastin 45-54)

Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (C-terminal amidation, RF-amide motif)

CAS: 374675-46-7

Molecular Weight: ≈1302 Da

Source: Minimal active fragment of the precursor protein (145aa) encoded by the KISS1 gene after enzymatic digestion

Dosage Form: Lyophilized powder

II. Core Mechanism (Master Switch of the Reproductive Axis)

KP-10 is an upstream core regulator of the HPG axis (hypothalamus-pituitary-gonadal axis), with precise and potent effects:

Receptor Activation

Binding to KISS1R (GPR54, Gq/11 coupled), mainly expressed in hypothalamic GnRH neurons

Activation of PLC → IP3 → Ca²⁺ release → PKC, directly depolarizing GnRH Neurons trigger pulsatile GnRH release

Hormonal cascade (core pathway)

GnRH↑ → Pituitary release of LH (luteinizing hormone)↑, FSH (follicle-stimulating hormone)↑

Male: LH↑ → Testosterone↑; FSH↑ → Sperm production↑

Female: LH↑ → Ovulation, corpus luteum formation; FSH↑ → Follicle development, estrogen↑

Key characteristics

Minimum activity: Only 10 peptides, containing a complete RF-amide pharmacophore, with affinity and potency comparable to the KP-54 receptor

Extremely short half-life: ≈4 minutes, rapid and short-lived action, suitable for pulsatile regulation

Pulse dependence: Physiological pulsatile administration is necessary to effectively activate the HPG axis; continuous infusion has poor effects

III. Core functions (reproduction + metabolism + tumor)

1. Reproductive regulation (most crucial)

Puberty initiation: KP-10 is the "switch" for puberty; increased expression triggers GnRH 1. **Pulse, Initiating Sexual Development:** Hypogonadotropic hypogonadism (IHH): Restores LH/FSH/testosterone/estrogen, improving secondary sexual characteristics and fertility.

Infertility/Ovulation Disorders:

Females: Induces ovulation, used for PCOS and hypothalamic amenorrhea.

Males: Increases testosterone and sperm count/motility, treating oligospermia and asthenospermia.

Precocious puberty/Abnormal sexual development: Regulates GnRH pulses, used in central precocious puberty (CPP) research.

2. **Metabolic and Energy Balance:** Regulates appetite, weight, and insulin sensitivity, connecting reproduction and metabolism (KNDy neurons co-express NKB/Dyn).

Improves obesity-related reproductive function decline.

3. **Tumor Suppression (Metastin):** Originally named Metastin, initially discovered as a tumor metastasis suppressor.

Inhibits melanoma and breast cancer cell migration and invasion, induces apoptosis, and reverses EMT.

IV. Dosage and Administration (Research/Clinical Protocols)

1. **Reconstitution:**

Soluble: 0.9% benzyl alcohol antibacterial water (BAC Water), 1-2 mL Dissolve 5-10 mg

Instructions: Pour along the side of the bottle, gently swirl to mix, do not shake vigorously

Storage: Refrigerate at 2–8°C after reconstitution